Mark’s focus is to “do the appropriate science, to answer the questions, to drive the project, to meet the business needs”.

Ph.D. scientist and consultant with 28 yrs experience in large and start-up pharma R&D with a passion to define, streamline, and implement strategies to efficiently drive and deliver phase optimized NCEs for oral, inhaled, and topical programs to the development pipeline.

Mark has a passion to apply his technical and managerial R&D experience, commitment, and creativity to overcome technical and logistical hurdles, especially regarding discovery support and pre-clinical programs. Having a Ph.D. in Medicinal Chemistry from the University of North Carolina-Chapel Hill School of Pharmacy and B.S. and M.S. degrees in Chemistry along with extensive analytical and physical properties experience, Mark is well placed to serve as an interface across a diverse range of discovery and development programs. As highlighted in more detail below, Mark’s business strengths include working well with teams, being goal focused, multi-tasking, identifying technical gaps and processes requiring improvement, and implementing change.

  

Leadership

  • Pharmaceutical Development Manager and Team Leader for multiple inhaled, oncology, and antiviral pre-clinical “developability” programs and also for process improvement initiatives spanning multiple global sites.
  • Exceptional teamwork, coordination, and communication skills spanning numerous matrix teams to define expectations to deliver phase optimized products for GLP Safety Assessment and Phase I clinical trials.
  • Proven technical mentor and trainer to develop highly productive teams.
  • Technical

  • Recognized technical trouble-shooter and “go to” resource
  • Initiated and expanded technical capability across various organizations
  • Physicochemical properties and stability evaluation, version/polymorph screen support, formulation screening, DMPK and GLP Safety Assessment support
  • Analytical: HPLC and GC method development and phase appropriate validation
  • Physical Properties: rheology, viscosity, optical microscopy, SEM, FTIR, DSC, TGA, XRD, GVS, osmolality, particle sizing, zeta-potential, solubility, small-scale micronization
  • Mark and his wife have 2 grown sons and currently live in Durham, NC USA. He is an avid bicyclist and enjoys volunteering to repair homes to be warmer, safer, and drier for low income families.